Depression is real. Check out my amygdala.

Using functional magnetic resonance imaging, researchers have found brain changes in preschool-age children with depression that are not apparent in their nondepressed peers.

The study, in the July issue of The Journal of the American Academy of Child & Adolescent Psychiatry, examined 23 children 4 to 6 years old who had been diagnosed with depression and 31 of their healthy peers. None of the subjects were taking antidepressants.

The children underwent M.R.I. brain scans while viewing pictures of happy, sad, fearful or neutral faces.


The researchers found that right amygdala and right thalamus activity was significantly greater in the depressed children than in the others, a finding that has also been observed in depressed adolescents and adults.

“We found something in the brain that is aligned with the idea of neurobiological models of depression — which parts of the brain are involved and how they interact,” said the lead author, Michael S. Gaffrey, an assistant professor in the department of psychiatry at Washington University in St. Louis.

“We can begin to use this information in conjunction with other information — symptoms, other biological markers — to identify and eventually prevent and treat this disorder.”



The Intricate Ties between Depression and Insecurity

Looking back, the hardest times in my life have occurred when I’ve felt insecure about my abilities, relationships, personality, or self-worth.

During these dark days, I inevitably found myself in embarrassing situations where I became insecurely attached to someone – or something – that I thought would make me whole.

Of course (and I know I am not alone in this), I learned the hard way that no person or thing can make me whole but myself.

Luckily, these difficult experiences were temporary, but not without emotional scars. Feeling insecure in a relationship creates anxiety over being abandoned and the feeling that every day is uncertain. It’s no wonder that those times when I felt insecurely attached were also accompanied by intense sadness.

That’s why I read with interest and appreciation that researchers in New York and Atlanta teamed up to study the neurological relationship between depression and insecure attachment.

In their study, 28 women (half of whom were depressed) participated in functional magnetic resonance imaging (fMRI) while viewing images of people important to them as well as strangers. They also completed the Beck Depression Inventory, the Adult Attachment Interview, and blood-oxygen level monitoring. The team then tested the connection, if any, between depression and insecure attachment.

Interestingly, the results showed that depression and insecure attachment involved related but distinct emotion-regulation processes in the brain.

The ways these processes interact indicate that insecure attachment may play a greater role in depression than previously realized.

There are other risks associated with feeling insecure in one’s relationships. For instance, another study found that feeling insecure in our attachments may increase risk for health problems later in life (read about that study here).

A third study found that the nature of our early attachments to others influences our romantic relationships in adulthood.

In my own life, I can certainly see how the ties between insecure attachment and depression may have played out during some of my greatest challenges. I can’t help but wonder whether knowing about the link between insecurity and depression could have helped me work through the pain in some way.

Oftentimes, knowledge is power and helps us move forward through understanding. Perhaps mental health professionals could use awareness as a type of intervention by helping people experiencing depression become aware of the connection between depression and insecure attachment.

It’s obvious that whether we feel securely or insecurely attached in our relationships has a profound effect on our emotional well-being. Perhaps one way to enhance our overall wellness is to nurture and strengthen those attachments that are so central to our lives.

Source: Written by Carrie Steckl, Ph.D. Updated: Dec 7th 2012

Galynker, I. I., Yaseen, Z. S., Katz, C., Zhang, X., Jennings-Donovan, G., Dashnaw, S., Hirsch, J., Mayberg, H., Cohen, L. J., & Winston, A. (2012). Distinct but overlapping neural networks subserve depression and insecure attachment. Social, Cognitive, and Affective Neuroscience, 7(8), 896-908.


About Jennifer Shay, LCSW, ACSW

Licensed Clinical Social Worker
This entry was posted in Mind. Brain. Relationships. and tagged , , , , , , . Bookmark the permalink.